En un presunto ataque terrorista en un hotel de Londres, un ministro del gobierno es asesinado. Mientras Sam y el equipo investigan el caso, antiguos amigos y funcionarios del gobierno pronto complican las cosas.

Hacer referencia a la parte 1, ya que esta es la historia continua de esa.

Sam se enfrenta a una intensa escrutinio durante una investigación oficial sobre las muertes de dos hermanos mientras estaban en prisión. Sus hallazgos son pronto desafiados por su colega, Leo Dalton, quien es llamado para realizar una segunda autopsia. Mientras tanto, una serie de asesinatos que están ocurriendo levantan sospechas sobre un exconvicto recién liberado. Él pasó años en prisión después de ser condenado por el asesinato de su esposa; las pruebas en su contra fueron presentadas por Sam durante uno de sus primeros casos. Sin embargo, durante su tiempo en prisión, él continuó negando su culpabilidad. Sam comienza a creer que alguien la está acechando, mientras que la policía tiene problemas para localizar al exconvicto.

Sam y Leo, patólogos colegas, están en lados opuestos de un caso judicial de alto perfil.

A John Doe is found months after his death; an attractive female agent for a championship athlete is believed to have jumped to her death from a rooftop. Forensic pathologists must sort out time and methods of death.

Sam Ryan steals a toothbrush to get the DNA of the father of the unborn child of a suspected suicide. Tangled relationships between an athlete and his family are amplified when his body is found hanging in her apartment. Police arrest the athlete's brother-in-law after an anonymous tip. Harry's attempts at determining time of death by the growth of maggots give a wrong answer.

Questions about a celebrated pathologist's accuracy in past cases leads to several exhumations; Sam Ryan is assigned to reexamine the remains. One particularly brutal murder conviction depends on the time of death being precise. Two crucial witnesses are found: one on her deathbed, anxious to get something off her chest, and the other dead behind a remodeled wall.

Sam is determined to find out how Dr. Sachs is able to pinpoint time of death so precisely, even if it means several convictions are overturned. A mother changes her plea to guilty, but Leo is still not satisfied that they have the truth. A loving daughter draws a picture for her prisoner dad that brings a confession. Dr. Sachs is found to have violated professional ethics, but what will serve the cause of justice best?