Cuando Stan se entera de que Hayley se ha fugado con Jeff y planea casarse en secreto, ofrece una recompensa a la persona que pueda detenerlos.

Stan tiene un clon de Steve creado para poder competir con Francine y ver quién puede criarlo mejor. Mientras tanto, Roger viaja a Tailandia para encontrar a Hayley y Jeff y obtener la recompensa monetaria.

El plan de Stan para superar la casa embrujada sofisticada del vecino sale mal cuando Roger libera a los asesinos en serie que había tomado prestados de la CIA. Mientras tanto, Steve se enfrenta a la venganza de Toshi cuando se enamora de su hermana Akiko.

Roger helps Stan fulfill his dream of owning a family fun restaurant, but Roger later takes over the project and fires Stan, causing him to create his own rival restaurant.

After all of Francine's repressed memories come back to her, she decides to be a stand-up comedienne and gets her own sitcom. Meanwhile, Steve finds a female companion for Klaus, but he quickly grows tired of her.

Stan invita a su hermano medio nativo americano a su casa todos los Días de Acción de Gracias para presumir de su riqueza, hasta que lo visitan en el Día de Acción de Gracias y descubren que es multimillonario.

Stan actúa como el presidente del jurado en el juicio de una de las personalidades de Roger, y está decidido a asegurarse de que el jurado lo declare culpable.

Stan y Steve accidentalmente disparan y matan a Santa Claus, pero es resucitado por sus elfos y está decidido a vengarse de toda la familia Smith.

Bored and disillusioned with her role as a housewife, Francine decides to take on a new identity. Meanwhile, Steve travels back in time to find a beautiful woman from a Nagel painting.

Stan y Francine hacen amistad con una pareja más joven, pero no pueden seguirles el ritmo en su estilo de vida muy activo. Mientras tanto, Steve y Roger intentan obtener un reembolso de un producto por teléfono.

With a flair for the dramatic, Roger invites Stan to attend one of his acting classes.

Roger moves out of his attic after learning of the life debt he got from Stan, but he starts to regret moving out of his home. When Roger tries to move back, he becomes heartbroken that Stan has replaced him with someone else. Roger does something desperate in order to repay Stan, but he gets injured by a polar bear at the zoo. Roger goes to Area 51 so he can get his fanny pack that contains a lubricant to heal Stan. Roger is able to save Stan, but they are chased by Area 51 personnel, the two are able to escape. Stan allows Roger to move back to his house and the two ditch Andy Dick, but he robs a pharmacy after he finds out the drugs he got from Stan are fake. Meanwhile, Steve becomes the new announcer, but he goes crazy with power. Snot is able to get Steve kicked off the morning announcements after he rants about his newfound power. Snot apologizes to Steve for getting him removed, but he forgives his friend. Unfortunately, Snot goes on the same power trip as Steve and he gets kicked off from the announcements. When Barry does the announcements, he starts cussing loudly in front of the student body. Principal Lewis becomes disgusted over the student's actions, but he unknowingly confesses his sins.

Stan recurre a medidas extremas y crueles para humillar a Steve y mantener su estatus de macho alfa en la casa, y Hayley y Jeff acuden al Director Lewis para recibir consejería matrimonial.

In an attempt to advance in the CIA, Stan begins playing golf with Senator Buckingham. Things are going well until Roger accidentally sells the senator's daughter to a drug lord, forcing Stan must choose between family and his career.

When Steve has trouble crossing over into the "cool kids" social circle, Klaus and Roger place their bets to see how quickly Roger can make him cool. Everything they try backfires until Steve becomes the in-crowds designated driver. Meanwhile, Stan and Francine take turns pranking each other.

After Snot professes his love for Hayley and gets shot down, Steve and Roger devise a plan to cheer him up. Roger dresses up as Steve's cousin from New Jersey, Jenny Fromdabloc, and Snot falls hard for her. Meanwhile, Stan want to live like a gentleman of the 1960s, complete with dark suits and dry martinis.

Stan and Francine fight over how to redecorate the house. It goes so far that they split the house down the middle and try to live without each other.

Stan becomes upset when Francine takes the receptionist job at his CIA office.

Stan spends some quality father-son time with Steve at the local zoo, but things go horribly wrong when Steve slips into a gorilla exhibit. Meanwhile, Roger bets Hayley that he can become a great Country singer and sets out to write the most heartbreaking song of all time.