Zoey Brooks and her younger brother, Dustin are new students at Pacific Coast Academy (PCA), an elite boarding school in California. While there, Zoey meets Chase Matthews, a friendly guy with high hopes of getting a girlfriend. Chase leads Zoey to her dorm, where she meets Nicole Bristow, a savvy girl who is easily attracted to hot boys, and Dana Cruz, a tomboy who does not accept diversity. A boy named Logan Reese challenges the girls to a basketball match. Logan picks his team, which includes Chase and Michael Barrett, another friendly guy who is willing to accept a challenge. Zoey chooses her team, which includes Nicole, Dana, and Quinn Pensky, a meddlesome scientist who is always inventing wacky items. The girls lose the basketball game by one point, prompting Logan to tease them. The coach of the basketball team then asks Zoey and Dana if they want to join the basketball team because they helped the most. Zoey accepts, while Dana says she will "think about it."

Zoey's roommates, Nicole and Dana, do not get along and fight every day, which drives Zoey crazy. Once Zoey tells them how annoying they are, they go against Zoey and all three of them are not friends anymore. Zoey decides to move in with Quinn, but soon finds her constant testing experiments bothering. Since Nicole and Dana are not her friends and Quinn is strange to be around with, Zoey starts hanging out with Chase. Zoey and Chase plan on watching a movie. Logan keeps on telling Chase that he is in love with Zoey and should try getting her away from making up with Nicole and Dana. As the movie rolls around, Zoey has already become friends with Nicole and Dana and the movie date, meant for 2, becomes a movie date of 4. Meanwhile, after spending all his money on gummy worms, Dustin is trying to find a way to earn money. He tries tutoring students how to speak Spanish only to fail miserably as Dustin hardly knows Spanish. In the end, he succeeds in earning money by playing guitar and sing his own song, "Gummy Worm Blues."

Zoey y las otras chicas están en el salón de chicas jugando a un juego llamado Confiesa o Estresa, donde un jugador debe contar un secreto o hacer un desafío. Chase y Logan visitan el salón durante el juego, y mientras están allí, Logan les regala a las chicas un enorme oso de peluche. Luego, Logan decide "descansar" en su habitación porque no se siente bien. Al día siguiente, los secretos personales de las chicas se escuchan por todo el campus, con nuevos secretos saliendo a la luz a medida que pasan los días. Pronto, las otras chicas culpan a Zoey por revelar sus secretos. Para detener todo esto, Zoey, Quinn y Nicole revisan el oso que Logan les dio, que ha estado en el salón desde entonces, y descubren que tiene una cámara web dentro. Zoey le pregunta a Chase si él está involucrado en este plan, pero él lo niega. Ambos se dan cuenta de que Logan ha estado espiando a las chicas después de mirar en su computadora portátil. Para atrapar a Logan en el acto, las chicas le dan algo para que vea, lo que hace que él lo cuente todo al Decano Rivers. Al final, Logan se mete en problemas y pierde su trabajo en Sushi Rox por fingir estar enfermo.

Dustin has a run-in with a school bully after helping him in class.

The girls decide to get even with the boys after falling victim to their pranks, but Zoey's prank puts all the girls at PCA in danger of being expelled.

Los niños de PCA tienen la tarea de hacer un comercial de televisión para un nuevo patinete.

Chase writes a play about an alien girl with Zoey as the lead, but gets severely flustered of when Logan gets the part of her would-be earthly boyfriend instead of him. Meanwhile, Dustin gets sick and Quinn tries to treat his ailments with some of her usual unconventional methods.

Quinn develops a crush on a boy named Mark, but when Zoey finds out that Mark's not interested, she takes it upon herself to organize a fake "date" between the two.

Las chicas se unen al comité de planificación de la "Primavera de Ensueño" y tratan de conseguir que una celebridad se presente en el evento.

Zoey's prototype backpack gets stolen by a PCA bookstore employee, Stacy, and the whole school goes crazy over 'Stacy's' backpack design.

In an attempt to get out of gym class, the kids expose a loophole in PCA policy and form a Disc Golf team.

The kids of PCA learn that the dates for the school dance will be determined by a personality test. What will happen when Dana ends up paired with Logan, Zoey is caught between two guys who cheated in the test, and Nicole is paired with a guy perkier than she is?

Zoey y sus amigos no pueden esperar para la fiesta en la playa que organiza PCA. Pero, debido a un experimento de Quinn, todos quedan inconscientes y se despiertan tarde. Incluso después de perder el autobús, Zoey está decidida a llegar a la fiesta. ¿Qué podría salir mal?