It's a big day for the Camden's as the twins start kindergarten. Lucy is pregnant but does not want to get maternity clothes yet. Simon and Georgia may be having sex. Ruthie gets in trouble at school.

A pregnant Lucy & Kevin learn they are going to have a girl. Simon tells his parents he is having sex with Georgia and is on probation at college. Eric decides to set up an abstinence pledge group at church, and Ruthie signs it.

Lucy is promoted to Associate Pastor at the church and faces the task of writing her first sermon. Simon starts going to a therapist and realizes he has been suppressing his guilt of a previous car accident. Ruthie wants to go on a date.

With Thanksgiving approaching, everyone seems to be planning something different. Lucy wants to host the big meal, Simon wants to stay at college, Mary is staying in Puerto Rico, and the others also have different plans. Annie is upset.

Shortly before Thanksgiving, Eric, Annie, and the twins are still not home; Eric has a cold and Annie already blames him for ruining the family Thanksgiving again. Simon has brought Georgia home but she refuses to tell anyone about her pregnancy until they tell his parents; later she tells him she lied so he wouldn't leave her. Pregnant Lucy is moody and takes advantage of her condition, driving Kevin and Matt mad; the weather cancels Martin's camping trip. Lucy gets Matt to take her to the supermarket where she faints, and Matt's limited medical-student knowledge bothers Dr. Klein. When Ruthie calls from Puerto Rico, lonely because Carlos' family is occupied with the baby, Martin assures her that Thanksgiving is celebrated in overseas territories too.