Nathan has gone to Las Vegas with his girlfriend Marnie and baby, Nathan Junior, with the express aim of using his super powers to defraud the casinos. Unfortunately, he gets caught and is led off to prison after making an unsuccessful phone call to Simon - or Barry as he calls him.

Whilst Kelly has trouble convincing people of her new power, the skills of a rocket scientist and Curtis finds his new gift, the ability to change sex useful when pursued by the police, the group learns that Nathan has gone to Las Vegas to use his super-power to cheat the casinos. He is replaced in the team by ladies' man Rudy, an old flame of Alisha, who has the ability to twin himself - somewhat unwittingly - when stressed. This incurs the wrath of pick-up Tanya who believes he is two-timing her and who gets her revenge by killing Charlie, the girl she saw Rudy kissing, and framing him for the murder. Fortunately the second Rudy comes to the rescue after Tanya is accidentally killed and once more the misfits find themselves burying two bodies and hoping to get away with it.

Curtis, prohibido de participar en atletismo por uso de drogas, ve la oportunidad de seguir compitiendo al adoptar una nueva identidad de género como Melissa, mientras se enamora de su compañera corredora Emma. Emma es bisexual y se siente atraída tanto por Curtis como por su alter ego Melissa, pero solo Simon conoce el secreto. Curtis/Melissa se convierte en el objeto no deseado de las atenciones sexuales de Shaun, Rudy y el entrenador de carrera Mark, quien droga la bebida de Melissa en una fiesta e intenta violarla, llevándose una sorpresa cuando Curtis regresa. Eventualmente, Curtis se ve obligado a admitir la verdad a los demás marginados y, después de salvarla de las acciones de Mark, a Emma.

In his alter ego as Super Hoodie Simon saves comic book fan Peter from a mugging. Later Peter recognizes his protector from his voice and the boys become friends, Simon explaining his destiny to become his future self by dying whilst saving Alisha. Peter, obsessed with his hero, uses his sinister gift to stop this - he draws cartoons in which the events come to pass in reality - and the pair have a climactic fight after Peter has abducted Alisha, though his comic strip reveals that he knew the outcome. Shaun meanwhile discovers Rudy's ability to clone himself whilst Kelly learns that Seth is still carrying a torch for the girlfriend whose death he caused when he was a drug dealer.

Elderly Jew Friedrich Hirsch travels back to 1930s Berlin to kill Hitler but fails and the Nazis use his mobile phone technology which alters history so Germany wins the war and present day Britain is under Nazi control, and none of the misfits know each other. Kelly and Simon are reluctant conscripts whilst Shaun, with Alisha, his unwilling girlfriend, is right hand man to odious Captain Smith. Seth, his ability to give and take super powers an asset to the Nazis, is imprisoned but Kelly and the other misfits spring him, leading to a shoot-out.

Kelly is accidentally body-swapped with a coma patient. Rudy gets anger management therapy.

After a one night stand Rudy loses his most prized possession and begs Simon for help to get it back. Curtis's power malfunctions, trapping him as Melissa.

Después de quitarle a Curtis el poder de cambiar de sexo, Seth le infunde el poder de reanimar a los muertos y traer de vuelta a su novia, como resultado de lo cual Seth deja a Kelly. Después de que Curtis revive a un gato muerto que ataca a su dueño, la pandilla se da cuenta de que algo está mal, ya que los cadáveres renacidos tienen gusto por la sangre, atacando a los vivos y convirtiéndolos en zombies rabiosos, incluyendo a un grupo de porristas que están ensayando en el centro comunitario. Seth se ve obligado a matar a su novia cuando ella se prepara para atacarlo, lo que le hace darse cuenta de que ama a Kelly. Desafortunadamente, los inadaptados tienen que matar a las porristas para salvarse, y con ellas, a otro supervisor de libertad condicional que también fue infectado.

Los inadaptados tienen que enfrentarse a los fantasmas de las personas que mataron después de que un médium los trajera de vuelta.