El equipo busca al joven de 15 años, Ryan Wallace, que está desaparecido y estaba obsesionado con la seguridad de su escuela después de perder a uno de sus padres y presenciar la caída de las torres el 11 de septiembre. Tanto Martin como Vivian regresan de baja médica. Jack parece estar protegiendo a su equipo y pierde la paciencia cuando Danny se pone en peligro innecesariamente.

The team's newest member, FBI rookie Elena Delgado, formerly of the NYPD, encounters a learning curve as she attempts to help search for missing 20-year-old Dina Kingston.

The backpack and ID of missing college coed Skye Petersen are suddenly dropped off at a thrift store seven years after Jack--and ultimately the legal system--determined she was murdered by her married professor with whom she'd just ended an affair.

The team searches for 25-year-old Korean-American Wendy Kim, who vanishes after a fight with her new boyfriend during her night shift at her parents' deli.

Jack and Danny head to Mexico to find wealthy American vacationer James Costin who was abducted, at the request of James' mother-in-law. While Vivian, Sam, Martin and Elena work the case back in New York, Jack encounters resistance from the locals. The team soon becomes suspicious of James's wife Lucy Costin, convinced she knows more about her husband's disappearance than she is saying.

Cuando el equipo investiga la desaparición de un hombre, encuentran fotos de pornografía infantil en su oficina en casa y en su computadora, todas de la misma niña pequeña. Sin embargo, el hombre que inicialmente parece ser un pedófilo en fuga rápidamente se convierte en una ayuda útil con la buena intención de encontrar a esta niña que ha sido sometida a una vida de tráfico humano y prostitución infantil.

Jack's friend Max Cassidy vanishes after leaving a message on his wife Anne's voice-mail. While investigating, Jack realizes that Max was having an affair, and that he has got in much deeper into an espionage case than he should have following the murder of his partner, Jimmy, a man Max had felt was too green for undercover work. Both Jack and Ann fear the worst as the team try to find Max.

While Jack tries to determine what to do about his increasingly frail and delusional father, Sam investigates an unidentified amnesiac woman in the mental ward of the hospital.

The FBI investigates the disappearance of Cole Warren, an FDNY paramedic who was last seen at the hospital after delivering a wounded gang banger. Warren is good at his job and is highly respected. He's stayed in his neighborhood and takes dangerous calls. He was a gang banger himself at one point and managed to get out of that life. He's taken an interest in a young man with the potential to make something of himself and not fall into the spiral that leads so many to crime and violence. Warren's past however catches up with him anyway. Meanwhile, Malone has to deal with his father's funeral and his relationship with Anne Cassidy.

After therapist Gina Hill disappears, the team investigates and initially suspects that one of her patients may be involved. After discussions with Gina's fiancé and her own therapist, the team follows the trail of clues to a bartender named Vince with an unusual ability to get good women to do whatever he wants them to. Martin continues to struggle with his recovery.

The FBI investigate the disappearance of Andy Reynolds who vanished after appearing in a police line-up in a rape case. He was released by the police but hasn't been seen since. The FBI learn that Andy had served 5 years in a military prison after confessing to to raping a young woman while stationed in Japan. Andy had a steady job working for another ex-Marine, Nelson Wolpert, but seems to have returned to Japan soon after the line-up. Jack Malone heads to Tokyo while the team in New York City continue the investigation. As they continue to gather evidence, the agents come to believe that Andy was innocent of the rape charge he confessed to.

Missing: one suburban housewife. Last seen arguing with a man outside of a Soho gallery. Husband more than a little worried.

A young boy goes missing in a car-jacking. His father worked for a large drug company and would like to sort things out by himself.

Un periodista agorafóbico desaparece.

Un mensajero en bicicleta desaparece. El equipo descubre que en realidad solo tiene 15 años, no 18 como sus empleadores creían. Al adentrarse en su vida familiar, descubren información bastante perturbadora.

A family - father, daughter and son - go inexplicably missing. The investigators find out from a school friend that the son witnessed something he shouldn't have.

Dos adolescentes desaparecen al mismo tiempo: un chico negro y una chica blanca. El equipo se enfrenta a la difícil tarea de encontrar a ambos adolescentes, lo cual se vuelve increíblemente complicado debido a toda la cobertura mediática otorgada a la adolescente blanca.

Former ADA Jennifer Nichols, now senior partner in a 'social' law firm, disappears after a visit form her allegedly stalking-prone ex Eric Jensen, but he proves inoffensive. She recently visited in jail Grant Stoker, the only caught member of a violent robber gang, and tricked him into betraying the mastermind. Jack suspects travel agency entrepreneur Allen Davis, who dated her but was bothered in the restaurant by the pregnant Lucy Stoker, adulterous wife of Grant who took the blame for her sake. Smelling a rat in the FBI office, Davis seizes the initiative drastically.